Life’s Stresses Got You Down? Reach for Adaptogens

Stress is harmful on the body.

Adaptogens help immunize against the harmful effects of stress.

When coping with stress and temporary bouts of fatigue, most Americans reach for that extra cup of coffee or energy shot to get through the day.  Others resort to alcohol, high-calorie snacks, cigarettes, or TV and the couch for an escape. But these habits are counter-productive; they can bring on disrupted sleep, withdrawal symptoms, or weight gain that eventually worsens mental and physical performance.

There may be a better way: adaptogens.

Swedish Herbal Institute researchers Alexander Panossian and Georg Wikman examined randomized, clinical trials on extensively studied adaptogens including rhodiola (Rhodiola rosea), schizandra berry (Schisandra chinensis), and eleuthero root (Eleutherococcus senticosus). They found that these and other adaptogens not only reduce stress and fatigue, but also improve attention and focus.

According to their recently published scientific review on adaptogens published in Current Clinical Pharmacology (1), the reason these herbs are effective may be because they stimulate biochemical pathways that help mediate the harmful effects of stress on the body. Among the findings from studies the authors included in their review were the following:

  • Rhodiola improved levels of emotional stability, self-esteem, and attention while also reducing fatigue and insomnia.
  • Eleuthero root reduced feelings of fatigue and increased resistance to low-oxygen settings, such as in deep-sea diving or high altitudes.
  • Schizandra increased work accuracy and feelings of general well-being, and decreased feelings of sleepiness and exhaustion.

From the Greek word “adapto” meaning “to adjust,” the term adaptogen is applied to any botanical that enhances resistance to stress without the side effects of conventional stimulants. Caffeine, according to the researchers, works by “tricking” the brain to make it more alert, but depletes its energy and resources. On the other hand, adaptogens increase the work capacity of the body or brain by being “stress-protective” or “restorative”.

Stress Vaccines

One of the main questions Panossian and Wilkman sought to answer was how adaptogens work. In their paper, they propose that adaptogens may help the body adapt to stress by inducing a mild stress response in the body. Acting like a “stress vaccine” adaptogens then inoculate against future sources of  stress.

In a sense, adaptogens mimic stress, creating an adaptive response in the nervous, cardiovascular, endocrine, immune and gastrointestinal systems. The authors suggest that through the regulation of stress with adaptogenic herbs, consumers may enjoy “enhanced mental and physical performance, and, possibly, increased longevity.”

Writing in a second review published in Pharmaceuticals in 2010 (2), the same authors wrote that these herbs normalize homeostasis (balance in the body) through several mechanisms akin to mild stress hormones. For example, active components of rhodiola, schisandra and eleuthero are structurally similar to catecholamines—primary regulators of stress—and other components resembling corticosteroids that help to inactivate a stress response.  Fortunately, what adaptogens won’t do is impair mental function or cause addiction.

Ionix® Supreme: Adaptogen-rich Stress Tonic

Ionix Supreme

Ionix Supreme is "nature's answer to stress."

Ionix Supreme, deemed “nature’s answer to stress”, is an adaptogen-rich drink designed with potent amounts of rhodiola, shisandra and eleuthero—as discussed by Panossian and Wilkman above—along with other beneficial herbs including:

  • Wolfberry (Lycium barbarum) acts as an adaptogen and an antioxidant for the maintenance of good health and increased mental and physical performance (3-5).
  • Ashwagandha (Withania somnifera) operates as an antioxidant for maintaining good health as well as stimulates liver detoxification (6). It may also support the brain (7) and immune function (8) while increasing the body’s resistance to stress (9).
  • Bacopa (Bacopa monnieri) acts as an antioxidant in the maintenance of brain health (10) and has been found to help maintain normal memory and cognitive function (11, 12).

With these herbal ingredients acting synergistically, drinking a shot or two of Ionix Supreme daily offers consumers an advantageous way of obtaining the protection adaptogens provide against stress. The drink can also help improve focus, attention or athletic performance.

Several recent studies also suggest that better management of psychological stress and minimizing its effects may also support more graceful aging. For example, a recent study published in August’s issue of Nature discovered that mice chronically infused with adrenaline, a hormone released by the body in reaction to stress, resulted in injured DNA (13). This study may help to explain why those individuals subjected to chronic psychological stress have shorter telomeres (14), the  protective caps on chromosomes whose length is considered a biomarker of aging.

Researchers are already studying several ways of combating the ill effects of stress on cells and their telomeres, including the role of exercise. What role will adaptogens have? Adaptogens in a supplement such as Ionix Supreme could be the key to beating stress, supporting healthier aging, and increasing longevity.

References

  1. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 2009;4:198-219.
  2. Panossian A, Wikman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity.  Pharmaceuticals 2010;3:188-224. doi: 10.3390/ph3010188
  3. Amagase H, Sun B, Borek C. Lycium barbarum juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr Res 2009;29:19-25. doi: 10.1016/j.nutres.2008.11.005
  4. Zhang R, Kang KA, Piao MJ et al. Cytoprotective effect of the fruits of Lycium chinense Miller against oxidative stress-induced hepatotoxicity. J Ethnopharmacol 2010;130:299-306. doi: 10.1016/j.jep.2010.05.007
  5. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum. J Altern Complement Med 2008;14:403-12. doi: 10.1089/acm.2008.0004
  6. Jeyanthi T, Subramanian P. Nephroprotective effect of Withania somnifera: a dose-dependent study. Ren Fail 2009;31:814-21. doi: 10.3109/08860220903150320
  7. Jayaprakasam B, Padmanabhan K, Nair MG. Withanamides in Withania somnifera fruit protect PC-12 cells from beta-amyloid responsible for Alzheimer’s disease. Phytother Res 2010;24:859-63. doi: 10.1002/ptr.3033
  8. Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 1996;50:69-76.
  9. Davis L, Kuttan G. Immunomodulatory activity of Withania somnifera. J Ethnopharmacol 2000;71:193-200. doi: 10.1016/S0378-8741(99)00206-8
  10. Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J Ethnopharmacol 2010;127:26-31. doi: 10.1016/j.jep.2009.09.056
  11. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9. doi: 10.1089/acm.2009.0342
  12. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology 2002;27:279-81.
  13. Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RG, et al. A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature. 2011 (August online issue). doi: 10.1038/nature10368
  14. Epel ES, Blackburn E, Lin J, Dhabhar FS, et al. Accelerated telomere shortening in response to life stress. PNAS 2004;101(49):17312-17315 doi: 10.1073/pnas.0407162101

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