PrintIsaGenesis: 10 Plant-Based Ingredients to Help Maintain Your Youth

For those wishing to maintain their youthful energy and vitality, IsaGenesis® represents a cocktail of selected botanicals and nutrients that reinforce the body’s own defenses against oxidative stress and underlying free radicals that can accelerate the process of aging.

Telomeres, the protective DNA sequences at the end of each chromosome, are essential to maintain genome stability within cells. Telomere length is considered a hallmark of biological aging. Normal cell division leads to gradual shortening of protective telomeres over time and is a process associated with normal aging. Lifestyle factors such as poor diet, stress, and exposure to environmental toxins are also linked to premature telomere shortening as well as other negative consequences for health (1-5).

Years of scientific study have identified nutritional strategies that are associated with benefits for healthy aging. Consistent with this research, a growing body of scientific literature suggests that antioxidant-rich plant foods and botanical ingredients can help to support telomeres and defend against the harmful effects of oxidative stress known to accelerate the cellular aging process (6).

  1. Milk Thistle – Milk thistle contains compounds including silymarin with demonstrated liver-protective and antioxidant effects (6-8).
  2. Ashwagandha – This popular herb has been used for centuries in Ayurvedic medicine known for its antioxidant and neuroprotective effects (9, 10).
  3. Horny Goat Weed – There’s evidence indicating that horny goat weed has antioxidant properties. It also supports healthy aging through different mechanisms, including support for immune and endocrine systems and benefits for metabolism and organ function (11-16).
  4. Grape Seed Extract – Grape seed extract has a high concentration of polyphenolic flavonoids which have been shown to improve parameters related to heart health and platelet reactivity (17-21).
  5. Turmeric – The curry spice contains curcumin and other curcuminoids which have demonstrated neuroprotective and immunoenhancing effects. It has also been shown to stimulate antioxidant defenses in the body (22, 23).
  6. Giant knotweed (a source of resveratrol) – Giant knotweed, as a natural source of resveratrol (also found in red wine), provides potent antioxidant and immune system support and has been linked with benefits for healthy aging (24-26).
  7. Pomegranate – This fruit has significant antioxidant activity due to its high polyphenol content. It has been demonstrated to support heart, metabolism, and detoxification systems (27-29).
  8. White, Green, and Black Tea – Various types of tea leaves contain biologically active compounds associated with many health benefits, including support for cognitive function and blood flow (30-33).
  9. Asian Ginseng – Shown to help improve glucose metabolism and circulation as well as moderate the immune response through its antioxidant properties (34, 35).
  10. Bilberry – Shown to support cognitive function and memory and protect the brain from oxidative stress (36-41).

Additionally, the inclusion of vitamin C (ascorbic acid) and B12 (a mix of methylcobalamin and cyanocobalamin) helps combat oxidative stress. Vitamin C plays a role in developing and maintaining a healthy antioxidant status (42, 43). Adequate vitamin B12 status is essential to maintain normal blood homocysteine levels. Elevated blood homocysteine is a known risk factor for oxidative stress (44, 45).

IsaGenesis Clinical Trial

Catalase is a protective enzyme naturally produced by cells that is key to defending against cellular damage caused by harmful, free-radical generating peroxides. Catalase neutralizes these harmful compounds to prevent damage within cells. Supporting the body’s defense against oxidative stress helps maintain normal telomere function and mitigates many of the factors that contribute to premature telomere shortening (1-5).

In a double-blind, randomized, placebo-controlled trial, IsaGenesis significantly increased levels of catalase in healthy adults after 12 weeks of daily use (6). Forty-three healthy, nonsmoking men and women ages 25-45 participated in a clinical trial which was conducted at a major university. The participants were randomly assigned to receive four capsules per day of either IsaGenesis or a placebo.

The participants provided blood samples before starting the trial, at four weeks, and after 12 weeks. Overall, the researchers observed a 15 percent increase in catalase levels in those participants who supplemented with IsaGenesis, compared to participants who received a placebo.

The clinical trial demonstrates that IsaGenesis not only includes botanicals and antioxidant nutrients to support the body’s defense against oxidative stress, but their combination is also shown to stimulate the body’s own powerful antioxidant defenses.


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