The wait is over.
Nearly a year ago, we reported on the teaming up of Isagenix Founder and Master Formulator John Anderson and molecular biologist Bill Andrews, Ph.D. The two had just announced a strategic partnership wherein they would begin seeking out natural, safe compounds to create a revolutionary product that could help “turn back the clock” on aging.
The focus of their research would be telomerase, the enzyme that maintains telomeres, or the protective caps of chromosomes that shorten with age. Telomere length was already starting to become an exciting new biomarker of aging (1-4).
Over the next few months, Anderson and Dr. Andrews worked to verify the activity of a number of natural compounds and their ability to assist in the maintenance of telomere health. Then, within a year’s time, Anderson and Dr. Andrews had fantastic news: “hits,” or discovery of natural compounds with potential of supporting telomere health; and a new product, Product B™ Antioxidants plus Telomere Support, which has garnered national media attention!
Telomere Health Lifestyle
As the months have passed, we’ve also highlighted several recent studies and scientific reviews on how diet and lifestyle can influence telomere length. As the science clearly points out, factors that contribute to oxidative stress play a key role in the speeding up of telomere shortening (2,3).
The major contributors of oxidative stress are exposure to environmental toxins, being overweight or obese, being overstressed, and eating a poor diet (4,5). To review, major strategies addressed previously for reducing oxidative stress and supporting the health of telomeres include:
- Exercising regularly (6,7)
- Maintaining a healthy weight (5)
- Eating more nutrient-dense, reduced-calorie foods (4)
- Meeting daily requirements for vitamins and minerals (especially antioxidant vitamins E and C, the B vitamins like B12, and the hormone-like vitamin D) (8-10)
- Consuming sufficient amounts of long-chain omega-3 fatty acids (DHA and EPA) (11,12)
- Limiting exposure to environmental toxins, especially from smoking or excessive drinking (2,3)
- Supplementation with specific bioactives that guard against oxidative stress or that promote the efficient activity of antioxidant enzymes (such as coQ10, green tea, milk thistle, curcumin, and resveratrol) (13-15)
- Reducing or managing stress through exercise and meditation (6,7,16)
- Practicing healthy sleep habits (16)
- Encouraging detoxification and reducing oxidative stress through reduced calories and supplementation on Cleanse Days and Shake Days (17,18)
- Consuming quality protein (such as whey) containing higher concentration of amino acids that help maintain glutathione levels (2,19, 20)
Many of these strategies are enhanced with regular use of an Isagenix system and the company’s Pillars of Health products:
- IsaLean Shake
- Ionix Supreme
- Cleanse for Life
- Ageless Essentials Daily Pack
The products used on Shake Days and Cleanse Days, respectively, help people maintain a healthy weight, achieve optimal nutrition, and limit their exposure to oxidative stress.
Introducing Product B
Isagenix introduced Product B at the 2011 “Ignite Your Future: Stay Young Forever” Celebration on Aug. 14, 2011. The billion-dollar breakthrough product, importantly, is now included as part of Ageless Essentials Daily Pack. Ageless Essentials with Product B is a matter of ultimate convenience for telomere protection based on the latest research and technology. The individually wrapped A.M. and P.M. packets contains each of the following:
- Product B Antioxidants plus Telomere Support combines the cutting-edge science in the field of telomere support with oxidative stress-fighting antioxidants that help you regain and maintain a more youthful vitality. A complex blend botanicals and vitamins that goes to work targeting the sources of aging and protecting your telomeres, and you, from harmful free radicals that speed up aging and contribute to poor health.
- Essentials for Men or Women, now featuring advanced disintegration and absorption technologies, provides the body with a steady stream of essential vitamins and minerals at timed intervals throughout the day.
- Ageless Actives provides coQ10 (ubiquinone) in a tri-lipid solution that is 800 percent more absorbable than other forms. It also contains 1,000 IU per serving of vitamin D3, which enhances the body’s absorption of calcium and maintains a strong cardiovascular system, and 250 mg of resveratrol per serving, which is equivalent to more than 100 glasses of red wine. Red grape and pomegranate extracts also help protect cells from the effects of free radicals.
- IsaOmega Supreme comes in a fresh, lemony taste and provides fish oil with a high concentration of DHA and EPA long-chain omega-3 fatty acids (1,200 mg) to meet recommendations for cardiovascular health. Each batch of IsaOmega Supreme is third-party tested for top-quality purity, meaning free of heavy metals, PCBs and dioxins.
- C-Lyte provides vitamin C as a variety of mineral ascorbates to be gentle on the stomach and provide the extra antioxidant protection the body needs in an environment of constant bombardment from oxidative stressors.
Maintaining healthy telomeres has never before been so easy. Forget about having to have multiple bottles to meet nutritional requirements and address the underlying mechanisms of aging. Ageless Essentials with Product B supplies a scientifically backed combination of vitamins, minerals, and bioactives the body needs to support healthy telomeres.
The product also fits directly in to almost anyone’s lifestyle of Cleanse Days and Shake Days as part of major Isagenix Paks for weight management, total health and longevity.
Welcome to a new era of ultimate telomere protection and youthful aging.
1. Cawthon RM, et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003;361:393–5.
2. Kurz et al. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004.
3. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-44.
4.Cassidy A, De V, I, Liu Y et al. Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr 2010;91:1273-80.
5. Kim S et al. Obesity and weight gain in adulthood and telomere length. Cancer Epidemiology Biomarkers & Prevention 2009; 18: 816-20.
6. Puterman E, et al. The power of exercise: buffering the effect of chronic stress on telomere length. PLos One 2010 May 26;5(5):e10837.
7. Cherkas L, et al. The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length. Arch Intern Med 2008;168(2):154-158.
8.Xu Q, Parks CG, DeRoo LA, Cawthon RM, Sandler DP, Chen H. Multivitamin use and telomere length in women. Am J Clin Nutr 2009;89:1857-63.
9. Richards JB et al. Homocysteine levels and leukocyte telomere length. Atherosclerosis 2008;200: 271-77.
10.Richards JB et al. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr 2007; 86: 1420-5.
11. Farzaneh-Far R et al. Associations of Marine Omega-3 Fatty Acid Levels with Telomeric Aging in Patients with Coronary Heart Disease. JAMA 2010; 303(3):250-7.
12. Lee JH et al. Omega-3 fatty acids for cardioprotection. Mayo Clin Proc 2008;83(3):324-332.
13. Chan R et al. Chinese tea consumption is associated with longer telomere length in elderly Chinese men. Br J Nutr 2010 Jan;103(1):107-13. Epub 2009 Aug 12.
14. Han KC et al. Genoprotective effects of green tea (Came!ia sinensis) in human subjects: results of a controlled supplementation trial. Br J Nutr. 2010 Sep 1:1-8
15. Smoliga JM, et al. Resveratrol and health—A comprehensive review of human clinical trials. Molecular Nutrition & Food Research 2011.
16. Jacobs TL et al. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology 2010.
17.Heibronn, LK, et al. Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr 2005;81:69-73.
18.Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol 2007;42:709-12.
19. Sekhar RV, et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Amer J Clin Nutr 2011. doi:10.3945/ajcn.110.003483.
20. Rayman MP, et al. Effect of supplementation with high selenium yeast on plasma lipids. A randomized trial. Ann Intern Med 2011 May 17;154:656-665.