Antioxidant combination improves arterial elasticity, according to recent study.

Among the several ingredients in Ageless Essentials with Product B are vitamin C, coenzyme Q10 (coQ10), vitamin E, and selenium. A recent study has found that this combination improves arterial elasticity when taken long term.

Arterial elasticity refers to how stiff or elastic arteries are, and more elastic means the better it is for your overall health and heart. Arteries become more rigid generally with age, hypertension or atherosclerosis.

The randomized, controlled trial (1), published in Nutrition and Metabolism, compared the effects of daily supplementation of the combination versus a placebo over six months on 70 participants who had at least two cardiovascular risk factors (hypertension, diabetes, high triglycerides, low HDL cholesterol, or smoking). After six months, the antioxidant-supplemented group showed significantly increased large and small arterial elasticity compared to placebo.

The cardiovascular benefit was also associated with better maintenance of glucose and lipid metabolism as well as blood pressure.

“We have demonstrated that combined antioxidant supplementation with vitamin C, vitamin E, coenzyme Q10 and selenium has beneficial effect on glucose and lipid metabolism, blood pressure and arterial compliance in patients with multiple cardiovascular risk factors,” the authors wrote. “The findings of the present study justify investigating the overall clinical impact of antioxidant treatment in this population,” wrote the authors.

Previous studies have found each of the nutrients deliver other benefits to the cardiovascular system and to myocardial function.

Vitamin C status is associated with vascular endothelial function, healthy blood pressure and protection against oxidative stress. In young women, higher plasma levels of vitamin C are associated with better maintenance of blood pressure and levels of C-reactive protein (CRP) (2, 3). CRP is a protein that when measured in the blood reflects the amount of swelling in the body, and high levels can get in the way of having a healthy heart.

CoQ10 plays a key role as a fat-soluble antioxidant involved in the health of myocardial tissues and their function. Supplementation not only helps the body to fight off oxidative stress, but has also shown to increase physical performance and power in athletes and non-athletes alike (4, 5). CoQ10 is also important for recycling vitamin E.

Vitamin E is associated with better cardiovascular health when combined with other antioxidants and micronutrients in the diet (6). In addition, increased consumption of polyunsaturated fats also increases the requirement for the nutrient. In a survey of vitamin E intake of approximately 10,000 American adults (7), more than 90 percent failed to meet current recommendations for vitamin E intake!

Selenium is a trace mineral with antioxidant properties because it is required for the function of selenium-dependent enzymes known as selenoproteins. Selenoprotein examples include glutathione peroxidase, a key antioxidant enzyme involved in protecting against oxidative stress, which can harm cardiovascular health. Supplementation is shown to assist in reducing oxidative stress in overweight adults (8).

Ageless Essentials Daily Pack features the following: C-Lyte, which provides 520 mg of vitamin C per day as mineral ascorbates that are easier on the stomach; Ageless Actives, providing 100 mg of coQ10 per day in a lipid-solubilized form developed by Bill Judy, Ph.D. The coQ10 is eight times (800 percent) more absorbable than typical dry powder forms;  Essentials for Men or Women, providing 90 IU of vitamin E (as natural mixed tocopherols and d-alpha tocopheryl succinate) and 100 mcg of selenium per day. With complementary nutrients such as fish oil (omega-3s) and vitamin K2, Ageless Essentials Daily Pack represents a convenient strategy for better cardiovascular health

References

1. Shargorodsky M et al. Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr Metab (Lond) 2010;7:55. doi: 10.1186/1743-7075-7-55

2. Block G et al. Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women. Nutr J 2008;7:35. doi: 10.1186/1475-2891-7-35

3. Judy WV, et al. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. Clin Investig 1993;71(8 Suppl):S155-61.

4. Gokbel H, Gul I, Belviranl M, Okudan N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 2010;24:97-102.

5. Ylikoski T, Piirainen J, Hanninen O, Penttinen J. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol Aspects Med 1997;18 Suppl:S283-S290.

6.  Jialal I and Devaraj S. Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med 2000;342:154-60.

7. Maras JE, Bermudez OI, Qiao N, Bakun PJ, Boody-Alter EL, Tucker KL. Intake of alpha-tocopherol is limited among US adults. J Am Diet Assoc 2004; 104 :567 –75. doi: 10.1016/j.jada.2004.01.004

8. Savory LA, kerr CJ, Whiting P, Finer N, McEneny J, Ashton T. Selenium supplementation and exercise: effect on oxidative stress in overweight adults. Obesity 2011 May 19. [Epub ahead of print]. doi:10.1038/oby.2011.83

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