heart health

Statin drugs deplete coQ10 levels.

Did you know? Statin drugs can cut your levels of coQ10 by almost half, leading to fatigue and muscle weakness. Only the right supplement can help restore levels of this energy-producing antioxidant.

With recent news of revised guidelines for statin therapy by the American Heart Association and the American College of Cardiology, estimates are that prescriptions for these cholesterol-lowering drugs could more than double in the United States in efforts to curb heart attacks and strokes (1).

But such drastic changes in the way cardiologists prescribe these drugs could have unintended consequences – in the form of widespread low levels of coQ10. In one study, for example, statin therapy depleted average serum levels of coQ10 in subjects by up to 49 percent after only 30 days (2).

The problem is in the mechanism by which statins work. Clearly effective, these drugs lower cholesterol by blocking the action of the enzyme involved in the synthesis of cholesterol called HMG-CoA reductase. However, the same enzyme is also involved in the production of coQ10.

Low coQ10 levels in the body—as a normal consequence of aging or statin therapy—are linked to a number of health consequences including chronic fatigue, muscle weakness, a lack of interest in exercise, and others. These health consequences, research shows, can be avoided through supplementation with coQ10. Only recently, a randomized controlled trial found that supplementation with sufficient coQ10 (300 mg/d) was effective in enhancing antioxidant status (including vitamin E status) in patients on statin therapy (3).

However, not all coQ10 supplements are effective in raising coQ10 levels in the blood. In most commonly used powder supplements, in fact, only about 1 percent of the CoQ10 is absorbed into the body. There is also the problem of poor quality supplements, which may not contain amounts stated on labels.

Exercise and a balanced diet are key for supporting heart health. Additionally for those taking a statin, an effective, quality supplement is essential for raising coQ10 to levels that are associated with improved antioxidant status and greater energy levels. Look no further than Ageless Actives, which contains lipid-solubilized coQ10 shown clinically to increase effectiveness by eight times (800% greater absorption and bioavailability).

When taking a statin, get the right coQ10 for youthful energy.


  1. Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults. Journal of the American College of Cardiology. 2013; doi: 10.1016/j.jacc.2013.11.002.
  2. Rundek T, Naini A, Sacco R, Coates K, DiMauro S. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol. 2004;61(6):889-892. doi: 10.1001/archneur.61.6.88.
  3. Lee B, Tseng Y, Yen C, Lin P. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J. 2013; doi: 10.1186/1475-2891-12-142.