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The ingredients in e+ shot explain its unique energizing benefits.

Whether you use it for a morning jolt, an afternoon pick-me-up, or an exercise elixir, Isagenix e+ Natural Energy Shot has become an essential tool for many to stay energized throughout the day. But do you really know what’s inside e+ and how it works to give you that healthy boost of energy?

When you break the seal of the two-ounce bottle, the first thing you notice is the aroma of crisp apple and pomegranate. That’s right—natural juices and no artificial flavors, sweeteners, or colors are used in e+, or any Isagenix product for that matter.

Although the delicious taste can be reason enough to enjoy the beverage, the real magic happens after you slug down the shot. With about as much caffeine as a cup of regular coffee, e+ gives you a healthy energy boost—all for only 35 calories. What’s more, the source of caffeine in e+ is from yerba mate and green tea extracts.

“Vitamin P”

Yerba mate is an herbal beverage popular in South America made from dried leaves of the Ilex paraguariensis plant and is a natural source of caffeine. Research has linked yerba mate consumption to many health benefits—including heart health and antioxidant protection—that are largely attributed to its high concentration of bioactive compounds including polyphenols and flavonoids.

Polyphenols are the most abundant antioxidant in the human diet, topping all other phytochemicals (compounds that occur in plants) and even known dietary antioxidants such as vitamin C, vitamin E, and carotenoids (1). Flavonoids, also known as bioflavonoids, are a type of polyphenol and were even once referred to as “Vitamin P” due to their key role in health.

Green tea is made from the leaves of the Camellia sinensis plant and is also a natural source of caffeine. In addition to giving you a boost, the catechins—another type of polyphenol with antioxidant properties—present in green tea extract have been shown to stimulate thermogenesis (i.e. support calorie- and fat-burning potential), increase antioxidant status, and reduce oxidative stress from free radicals (2, 3).

Just Enough Natural Caffeine

Research shows it takes 15 to 45 minutes after ingestion for caffeine levels to elevate in the body with peak concentrations evident within one hour (4). As caffeine levels start to rise in the body, the caffeine molecule crosses the blood-brain barrier and blocks the neurotransmitter, adenosine, from binding to receptors on the brain. Think of adenosine as the “lazy” neurotransmitter—it signals the brain to slow down nerve cell activity causing you to feel drowsy and tired. In the brain, this also causes blood vessels to dilate, possibly to allow more oxygen to get to the brain during sleep.

Conversely, when caffeine binds to the receptors on the brain, nerve cells speed up. As a result, brain cells start firing off signals that make the body feel like it is in an alert state. This leads to the release of hormones causing a cascade of physiological responses, all of which are aimed at making you more focused and in control. This explains why after your e+ shot, you feel energized, primed, and ready to take on whatever comes your way.

There’s no need to consume dangerously excessive doses of synthetic caffeine to gain energizing benefits, as supplied in some other energy drinks. In e+ shot, natural caffeine from yerba mate and green tea is only supplied in moderate amounts that are healthy. The drink is fast acting and its supply of energy is long lasting. A half bottle is recommended for moderate energy and a whole bottle for maximum energy. Recommendations are to not exceed two bottles daily and to avoid mixing with alcoholic beverages. In addition, those who are under age 18, pregnant, or with any medical conditions should check with a physician before using e+.

Fatigue-Fighting Adaptogens

While the naturally sourced caffeine from green tea and yerba mate are key components of e+, the real superstar is the adaptogenic blend. Adaptogens are herbs and botanicals that have been shown to help normalize the body’s response to stress and improving the body’s capacity to perform and function under stressful circumstances. They do this by stimulating biochemical pathways that decrease the body’s sensitivity to harmful stressors, resulting in stress “protection” (5, 6).

Take this scenario: You are standing at the top a ten-foot tall diving board. There are butterflies in your stomach, your pulse rate quickens, you get nervous, feel flushed, perhaps your legs feel a little weak as you inch towards the edge. Your imagination and anticipation have activated the nervous and endocrine systems, sending hormones surging though your body. Finally, you jump. The second time around, you don’t have such a severe hormonal flux, the butterflies aren’t as active, and your limbs are more compliant. What was the difference? Your body had experienced the stress before, and it had built up a resistance. This conditioning is the principle behind adaptogens and how they work to strengthen the body’s response to stress.

The specific blend found in e+ was inspired by the research of the late Dr. Israel Brekhman, a pioneer in the study of adaptogens. Some of the stress-modulating, fatigue-fighting adaptogens in e+ include:

  • Eleuthero (Eleutherococcus senticosus): Also known as Siberian ginseng, this thin, thorny shrub has been shown to improve endurance performance by supporting optimal cardiovascular functions and oxygen uptake (7).
  • Rhodiola (Rhodiola rosea): This adaptogenic plant is native to the arctic and mountainous regions of Europe, Asia, and America. It has been used in traditional Chinese medicine and has been shown to increase energy, reduce fatigue, and help maintain cognitive function during stressful circumstances (8).
  • Hawthorn Berry (Crataegus oxyacantha): Evidence supports hawthorn berry’s ability to mediate both the physiological and psychological stress response in the body (9).

The novel combination of energy-boosting caffeine and stress-modulating adaptogens in e+ Natural Energy shot set it apart from any other energy beverage on the market. The blend of natural ingredients makes it a healthy and safe alternative to high-calorie, excessively caffeinated, artificially sweetened energy drinks and shots. You only get the best with Isagenix, and e+ is no exception.


  1. Scalbert et al. Polyphenols: antioxidants and beyond. J Clin Nutr 2005;18:2155-2175.
  2. Nago et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-nodified LDL in men. Am J Clin Ntr 2005;81(1):122-9.
  3. Higdon et al. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Nutr 2003;43(1):89-143.
  4. Goldstein ER, et al. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr 2010;7:5.
  5. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 2009;4:198-219
  6. Panossian A, Wikman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity.  Pharmaceuticals 2010;3:188-224. doi: 10.3390/ph3010188
  7. Kuo et al. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Chin J Physiol 2010;53:105-11.
  8. Darbinyan V, et al. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7:365-71.
  9. Can O, et al. Effects of hawthorn seed and pulp extracts on the central nervous system. Pharm Biol 2010;48(8):924-31.